Line a baking sheet with low sides with paper towels and top with a wire rack.
In a small mixing bowl combine the cayenne pepper, brown sugar, chili powder, paprika, garlic powder, kosher salt and pepper.
In another bowl, combine the flour and 2 Tablespoons of the spice mixture; set aside.
Rub both sides of the chicken tenders with the remaining spice mixture, coating the chicken pieces.
Transfer the chicken to a shallow bowl and pour the buttermilk and hot sauce over the chicken, mix well and marinate for at least 30 minutes or up to 4 hours. If marinating for longer than 30 minutes, cover the bowl with plastic wrap and refrigerate.
Heat the oil over medium-high heat in a large skillet with deep sides.
Remove each chicken tender from the marinade and coat with the reserved flour mixture.
Let the chicken stand for another 5 minutes.
Fry the tenders, in batches, until golden brown on both side, turning once.
Remove the chicken from the oil and transfer to the prepared wire rack so any excess oil can drain off.